教育學院
Permanent URI for this communityhttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/1
教育學院成立於民國44年6月5日，時值臺灣省立師範學院改制為臺灣省立師範大學，初設教育、社會教育、體育衛生教育、家政教育、工業教育五個學系，發展迄今，本院共設有7個學系（均含學士、碩士及博士班）、5個獨立研究所、1個院級在職碩士專班。
本院為國內歷史最久之教育學院，系所規模、師資，及學生品質向為國內首屈一指，培育英才無數，畢業校友或擔任政府教育行政單位首長及中堅人才、或為大學校長及教育相關領域研究人員、或為國內中等教育師資之骨幹、或投入民間文教事業相關領域，皆為提升我國教育品質竭盡心力。此外，本學院長期深耕學術，研究領域多元，發行4本 TSSCI 期刊，學術聲望備受國內外學界肯定，根據 2015 年 QS 世界大學各學科排名結果，本校在教育學科名列第22名，不僅穩居臺灣第一，更躍居亞洲師範大學龍頭。
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Item 藍光照射合併光敏感物質A2E對人類視網膜上皮細胞之傷害效應(2019) 陳律安; Chen, Lu-AnA2E (N-retinylidene-N-retinylethanolamine)為眼睛視循環之維生素A衍生物，可隨人體老化與褐脂質 (lipofuscin)漸進式地堆積於視網膜中，為眼底隱結 (drusen)形成的關鍵因子。已知A2E具光敏感性，經光線照射後可誘發活性氧自由基 (reactive oxygen species, ROS)生成，據統計現代人每日使用3C裝置的時間可長達9小時，暴露於藍光的風險增加。藍光因其高強度的光化學能量及高穿透特性可穿透瞳孔直達眼底視網膜，激發A2E光氧化反應，造成視網膜上皮細胞 (retinal pigment epithelium, RPE)損傷，進而導致黃斑部病變與視力下降。本研究目的在探討A2E合併藍光照射後對RPE細胞之負面效應。首先利用silica gel-C18管柱層析及陽離子交換樹脂進行A2E化學合成，並以1H-NMR及LC-MS/MS進行A2E結構鑑定。細胞試驗則選用人類視網膜上皮細胞株ARPE-19，分別探討該細胞經(1) 不同A2E作用劑量；(2) 不同藍光照射時間，以及(3) A2E合併藍光照射等條件下，對ARPE-19細胞之影響。利用CM-H2DCFDA與MitoSOX Red染劑分別進行胞內及粒線體ROS生成之分析；以SA-β-Gal kit判斷細胞老化程度。結果顯示，A2E於生理濃度 (9 μM)下，若合併藍光照射可顯著抑制ARPE-19之細胞增生與造成細胞死亡；同時可促進胞內及粒線體ROS生成並加速細胞老化；而介入維生素E (vitamin E)可減緩上述之負面效應。此顯示藍光照射所造成之RPE細胞損傷可能與A2E誘發之氧化壓力有關。綜合上述，本研究結果有助於建構藍光-視網膜損傷之細胞實驗模式，未來可應用於篩選護眼機能性成分，亦可作為開發護眼機能性食品之參考。Item Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women(Nature Publishing Group, 2006-03-01) Wu WH, Lu SC, Wang TF, Jou HJ, Wang TABackground: Vegetarians are generally deficient in long-chain n-3 fatty acids. Long-chain n-3 fatty acids have a beneficial effect on plasma lipid levels, and some studies showed that they had breast cancer suppression effect. One of the biomarkers of breast cancer risk is the ratio of urinary 2-hydroxyestrone (2-OHE1) to 16-hydroxyestrone (16-OHE1). Objective: To investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) supplementation on blood lipids, estrogen metabolism and oxidative stress in vegetarians. Design: Single-blind, randomized, placebo-controlled trial. Interventions: Twenty-seven postmenopausal vegetarian women were recruited. After a 2-week run-in period with 6 g placebo corn oil, the subjects were subsequently randomized to receive either 6 g corn oil (n=13) or 6 g DHA-rich algae oil (2.14 g of DHA/day) (n=14) for 6 weeks. Two subjects in corn oil group withdrew before completion. Main outcome measures: Plasma lipids, urinary 2-OHE1 and 16-OHE1, urinary F2-isoprostanes and plasma -tocopherol. Results: Plasma LDL-DHA and EPA level increased significantly by DHA supplementation. DHA decreased plasma cholesterol (C) levels (P=0.04), but did not influence the levels of plasma TG, LDL-C and HDL-C, -tocopherol, urinary F2-isoprostanes, 2-OHE1, 16-OHE1 and ratio of 2-OHE1 to 16-OHE1 as compared to corn oil. Conclusion: DHA supplementation at a dose of 2.14 g/day for 42 days decreases plasma cholesterol but neither does it show beneficial effects on estrogen metabolism, nor does it induce deleterious effects on the observed in vivo antioxidant or oxidative stress marker in postmenopausal vegetarian women.