短期雙參增補對下坡跑運動後脈波傳導速度及DHEA-S之影響
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2014
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背景：脈波傳導速度 (pulse wave velocity, PWV) 為心血管疾病指標。脫氫表雄固酮 (dehydroepiandrosterone, DHEA) 受促腎上腺皮質素刺激及細胞色素P450催化而生成，在循環系統形成硫酸脫氫表雄固酮 (DHEA-sulfate, DHEA-S) 存於體內，且與PWV呈負相關。人參能誘發血管舒張及增加ACTH分泌、丹參能擴張冠狀動脈及促進細胞色素P450酶表現，可能可以改善PWV及增加DHEA。目的：探討短期增補雙參對下坡跑運動後PWV及DHEA-S的影響。方法：招募20名健康且無規律運動習慣之男性受試者，依隨機分配與雙盲原則，連續增補7天雙參 (人參和丹參萃取物各250毫克) 或安慰劑，增補完24小時內進行75 %最大攝氧峰值 (75%VO2peak) 強度之30分鐘下坡跑 (-10˚) 運動，並於控制實驗、下坡跑運動前30分鐘、後90分鐘、24和48小時檢測PWV、血清DHEA-S、肌酸激酶、皮質醇濃度、主動關節活動度及肌肉痠痛指數。結果：兩組平均CK值於下坡跑運動後24及48小時皆顯著高於運動前 (p＜.05)，而主動關節活動度及肌肉痠痛指數於運動後各時間點皆顯著高於運動前 (p＜.05)；雙參組之PWV於運動後24與48小時顯著低於安慰劑組 (p＜.05)，但兩組平均DHEA-S值僅於運動後90分鐘至24小時顯著上升；皮質醇皆無差異 (p＞.05)。結論：雙參增補雖不能促進DHEA-S濃度增加，但能抵抗單次下坡跑運動所引發脈波傳導速度的上升。
Background: pulse wave velocity (PWV) is an indicator of cardiovascular disease. Dehydroepiandrosterone (DHEA) release is activated by adrenocorticotropic hormone and it is regulated by cytochrome P450. Most of DHEAs are sulfated as DHEA-S circulating in the body,and it is negatively correlated with PWV. Panax ginseng has been studied eliciting ACTH secretion, and Danshen can enhance the performance of the cytochrome P450 enzymes, which might contribute to the increase of DHEA. Purpose: to investigate effects of panax ginseng and salvia miltiorrhiza supplementation prior to an acute bout of downhill running exercise on PWV and DHEA-S secretion. Methods: twenty apparent healthy males were recruited to participate in this study. Participants were randomly assigned into panax ginseng and salvia miltiorrhiza supplementation (S, n=10) and placebo supplementation groups (P, n=10). Peak oxygen uptake was determined prior to experiment followed by a thirty minutes of downhill running at -10˚of slope that could elicit 75% of individual VO2peak. PWV, serum DHEA-S, creatine kinese, cortisol, visual analog scale (VAS), and active range of motion (AROM) were measured at control, 30 minutes pre-exercise, 24 and 48 hours post-exercise. Results: compared with baseline, CK of S and P group were significantly higher at 24 and 48 hours after exercise. AROM and VAS at 90 minutes, 24 and 48 hours post-exercise were significantly higher than pre-exercise; PWV of S group was significantly lower on 24 and 48 hours post-exercise as compared to P group (p＜.05), but DHEA-S of two groups at 24 hour post exercise was significantly higher than 90 minutes post-exercise, whereas there was no difference in cortisol response (p> .05). Conclusion: panax ginseng and salvia miltiorrhiza supplementation can prevent the increase of PWV induced from downhill running exercise, yet it is not associated with DHEA-S.
Background: pulse wave velocity (PWV) is an indicator of cardiovascular disease. Dehydroepiandrosterone (DHEA) release is activated by adrenocorticotropic hormone and it is regulated by cytochrome P450. Most of DHEAs are sulfated as DHEA-S circulating in the body,and it is negatively correlated with PWV. Panax ginseng has been studied eliciting ACTH secretion, and Danshen can enhance the performance of the cytochrome P450 enzymes, which might contribute to the increase of DHEA. Purpose: to investigate effects of panax ginseng and salvia miltiorrhiza supplementation prior to an acute bout of downhill running exercise on PWV and DHEA-S secretion. Methods: twenty apparent healthy males were recruited to participate in this study. Participants were randomly assigned into panax ginseng and salvia miltiorrhiza supplementation (S, n=10) and placebo supplementation groups (P, n=10). Peak oxygen uptake was determined prior to experiment followed by a thirty minutes of downhill running at -10˚of slope that could elicit 75% of individual VO2peak. PWV, serum DHEA-S, creatine kinese, cortisol, visual analog scale (VAS), and active range of motion (AROM) were measured at control, 30 minutes pre-exercise, 24 and 48 hours post-exercise. Results: compared with baseline, CK of S and P group were significantly higher at 24 and 48 hours after exercise. AROM and VAS at 90 minutes, 24 and 48 hours post-exercise were significantly higher than pre-exercise; PWV of S group was significantly lower on 24 and 48 hours post-exercise as compared to P group (p＜.05), but DHEA-S of two groups at 24 hour post exercise was significantly higher than 90 minutes post-exercise, whereas there was no difference in cortisol response (p> .05). Conclusion: panax ginseng and salvia miltiorrhiza supplementation can prevent the increase of PWV induced from downhill running exercise, yet it is not associated with DHEA-S.
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促腎上腺皮質素, 延遲性肌肉痠痛, 心血管疾病, adrenocorticotropic hormone (ACTH), delayed onset muscle soreness (DOMS), cardiovascular disease