壹、由森田-貝里斯-希爾曼產物合成(Z)-6氫-苯並[7,8]氧㖕並[4,3-b]喹啉與其衍生物貳、由森田-貝里斯-希爾曼產物簡單合成二苯甲烷衍生物的方法

Abstract

本論文主要分成兩個部份: 第一部分為利用森田-貝里斯-希爾曼產物合成(Z)-6氫-苯並[7,8]氧㖕並[4,3-b]喹啉與其衍生物，先以不同取代基的苯甲醛(1)和2-環己烯-1-酮(2-Cyclohexen-1-one，2)，以森田-貝里斯-希爾曼反應反應合成森田-貝里斯-希爾曼產物3，然後和乙醯氯反應成產物4，再經由SN2反應形成產物6，再藉由酸催化進行分子內的合環，形成八圓環產物7，最後再還原再進行一次分子內的合環，合成出最終產物8。 第二部分則一樣利用森田-貝里斯-希爾曼產物，和一、二級醇類經由酸催化進行芳香化反應，形成二苯甲烷衍生物及其他後續產物。This essay has two parts. In the first part, I use Morita-Baylis–Hillman adducts to synthesis (Z)-6H-benzo[7,8] oxocino [4,3-b]quinolone derivatives. First step, use bezaldeyde with different substitute(1) and 2-cyclohexen-1-one(2) to make Morita-Baylis-Hilman reaction to synthesis Morita-Baylis-Hilman derivatives(3). Second step ,use AcCl to make compound(4). Third step, use SN2 reaction and 2-hydroxybenzaldehyde to make compound(6). Four step, use acid and amine catalyst to make cyclolization to make compound(7). Final step, reduction reaction to make cylcolization again, to make the final compound(8).In the second part,also use the Morita-Baylis-Hilman adducts,and primary or secondary alcohol by acid catalyst and heat, to make the aromatization reaction, get diphenylmethane product and other derivatives.