高溫超導量子干涉元件之磁粒子諧波檢測與生物磁造影系統之開發與應用研究

Abstract

本研究利用High-Tc SQUID於屏蔽屋內建立一高溫超導量子干涉元件之磁粒子造影系統，已知磁流體具有高生物相容性，可應用於影像顯影及癌症標靶治療等，本研究開發高溫超導量子干涉元件之磁粒子造影系統，透過激發線圈給予磁場激發磁流體後，偵測磁流體的交流磁化訊號。在訊號分析的部分，擷取三倍頻訊號以提高訊雜比，並利用強度及相位資料分析進一步提升靈敏度。在影像方面，本系統以三維步進馬達來移動樣品進行掃描以取得磁流體磁訊號分布圖，並透過磁源反演算整合出高靈敏與高空間解析度之影像。該系統包含超導量子干涉元件、激發線圈與接收線圈，調整至訊號檢測最靈敏之狀態後，搭配反向串聯的梯度接收線圈降低背景雜訊。此系統架設於屏蔽屋內，透過計算相位資料調整樣品訊號強度後根據磁通耦合現象並選擇三倍頻，可避免生物體反磁性訊號、激發線圈的基頻訊號和減少其他頻段之干擾，因此該系統具有超高靈敏度的功能性檢測優勢。此整合影像技術未來可用於腫瘤細胞追蹤及影像顯影等，以驗證磁性粒子於生物醫學成像應用之可行性。In this study, we use High-Tc SQUID to build a high-temperature superconducting quantum interference element magnetic particle imaging system in a shielded house, magnetic fluid has high biocompatibility and can be used in image development and cancer targeted therapy. In this work, a magnetic particle imaging system based on HTS SQUID. After the magnetic field is excited by the excitation coil, the magnetic fluid's AC magnetization signal is detected. In the signal analysis part, the third frequency signal is captured to improve the SNR, and the intensity and phase data analysis is used to further improve the sensitivity. In terms of images, the system uses a three-dimensional stepping motor to move the sample for scanning to obtain a magnetic fluid magnetic signal distribution map, and integrates a highly sensitive and high spatial resolution image through magnetic source inversion. The system includes SQUID, excitation coils and receiving coils, adjusted to the most sensitive state for signal detection, with gradient receiving coils connected in reverse series to reduce background noise.This system is built in a shielded house, and integrates intensity and phase data analysis, magnetic flux coupling, and third frequency selection. It can avoid interference from biological diamagnetic signals, fundamental frequency signals of excitation coils, and other frequency bands. Therefore, the system has the advantage of ultra-high sensitivity and functional detection. This integrated image can be used for cell tracking and image development in the future to verify the feasibility of magnetic particles in biomedical imaging applications.