海洋深層水有機萃取物對高血脂倉鼠之降血脂效果

Abstract

高血脂(Hyperlipidemia)為造成肝臟及心血管疾病的危險因子，如非酒精性脂肪肝(Non-alcoholic fatty liver disease, NAFLD)與動脈硬化(Atherosclerosis)。高血脂起因於代謝性疾病或不均衡的飲食習慣。海洋深層水(Deep sea water, DSW)含有豐富的營養素，並具有抗氧化與抗發炎等特性。目前為止已有許多研究證明能預防或改善疾病。本篇研究欲探討飲用海洋深層水有機萃取物質調整血脂肪之成效。 實驗設計分為一般飼料控制組、高脂飼料高血脂誘發組，以及高脂飼料搭配高低劑量海洋深層水有機萃取物治療組，一共四個組別。高脂肪飲食引發高血脂、非酒精性脂肪肝與初期動脈硬化。飲用海洋深層水有機萃取物質有效抑制血脂上升，減少脂肪於肝臟累積並降低細胞凋亡蛋白表現。低密度脂蛋白氧化堆積於血管內皮易導致動脈硬化。海洋深層水有機萃取物質為一卓越的抗氧化劑，使血液中的自由基與脂質氧化物顯著降低。此外，海洋深層水有機萃取物質抑制細胞黏附因子於動脈內皮表現，降低血管阻塞風險。 透過有機萃取物所具備的抗氧化力與降低血脂的能力，能有效預防高血脂、肝臟與心血管疾病。Hyperlipidemia is a well-known risk factor for non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) like hypertension, atherosclerosis and stroke. Unbalanced eating habit or metabolic disorders lead to hyperlipidemia. Elevated blood cholesterol and triglyceride (TG) levels are important indicators of hyperlipidemia. Deep sea water (DSW) is characterized by abundant nutrients, antioxidant and anti-inflammatory effects. So far, DSW has been reported for therapeutic effects on several diseases. This study evaluated the therapeutic effect of DSW-dissolved organic matter (DSW-DOM) on hyperlipidemia hamsters. Animals were divided into four groups: normal diet (CON), high fat/cholesterol diet (HCD) and high fat/cholesterol diet with low or high dose of DSW-DOM (HCD-LD, HCD-HD). High fat/cholesterol diet caused hyperlipidemia, NAFLD and early atherosclerosis. DSW-DOM inhibited lipid profile elevation, reduced lipid accumulation and hepatic apoptosis. Buildup of oxidized low-density lipoprotein (ox-LDL) in endothelial cells caused atherosclerosis. DSW-DOM significantly reduced blood reactive oxygen species (ROS) and malondialdehyde (MDA). Furthermore, DSW-DOM inhibited expression of adhesion molecules on endothelium, reducing the risk of thrombosis. The anti-oxidant and hypolipidemic effects of DSW-DOM prevent hyperlipidemia, NAFLD and CVD.