金奈米棒包覆二氧化矽與溫感型水膠與其在藥物傳輸上的應用

Abstract

摘要 近年來，許多將無機奈米結構與生物系統相連接的材料已經陸續應用於生物醫學的領域。在本篇論文中，利用金奈米棒為模板，在金奈米棒外面包覆二氧化矽或者是聚合物。 在金奈米棒包覆二氧化矽的部份，我們成功合成出均勻二氧化矽包覆在金奈米棒的材料，並藉由完全溶解內部的金奈米棒來合成出具有中空性質的二氧化矽奈米膠囊，或是部份溶解內部金奈米棒，製備出內外為不同材料的中空二氧化矽奈米膠囊。 在金奈米棒包覆聚合物部份，我們合成出金奈米棒外面包覆一層溫感型水膠P(NIPAAm-co-AAc)。溫感型水膠在溫度高於其相轉移溫度時，會有去澎潤現象，而釋出內部的水分。利用這個性質，我們將藥物包覆於這個材料中，內部的金奈米棒可以吸收特定波長的雷射使溫度升高，當溫度高於水膠的相轉移溫度，即可達到藥物釋放的目的。 在此，我們選用兩種以上不同吸收波長的金奈米棒來合成這個材料，便可以利用不同波長的雷射來釋放不同的藥物。

Abstract Inorganic nanomaterials that interface with biological systems have recently attracted widespread interests in biomedical application. In this paper, we employ gold nanorods to be template to synthesize silica-coat or polymer-coating gold nanorods. The part of silica-coating gold nanorods is successful to synthesize uniform silica-coating gold nanorods. Furthermore, we can synthesis not only silica nanocapsule by dissolving gold nanorod completely, but hollow silica-coating gold nanorods. The part of polymer-coating gold nanorods, we can successfully synthesize thermo-responsive hydrogel-coated gold nanorods, poly(N-isopropylacrylamide-coAcrylic acid ) (p(NIPAAm-co-AAc)). Thermo-responsive hydrogel are observed that they are deswelling , then release water in hysrogel when heated above its lower critical solution temperature (LCST). Utilizing this property, we encapsulated drug in this material. The temperature of this material is raised when gold nanorods in core absorb laser of specific wavelength. It can be control drug release when temperature above LCST of hydrogel. At present,we use different gold nanorods that have different specific wavelength, it can successfully control release of different drug by absorbing laser of different wavelength.